P383 INFLAMMATORYAND DEGRADATIVE FACTORS IN MESENCHYMALSTEM CELLS ARE MODULATED BY HYALURONAN-BASEDPOLYMER SCAFFOLD
نویسندگان
چکیده
منابع مشابه
Degradative action of reactive oxygen species on hyaluronan.
Many human diseases are associated with harmful action of reactive oxygen species (ROS). These species are involved in the degradation of essential tissue or related components. One of such components is synovial fluid that contains a high-molecular-weight polymer--hyaluronan (HA). Uninhibited and/or inhibited hyaluronan degradation by the action of various ROS has been studied in many in vitro...
متن کاملHuman mesothelioma cells produce factors that stimulate the production of hyaluronan by mesothelial cells and fibroblasts.
The hyaluronan production by three human malignant mesothelioma cell lines and nine primary human mesothelial cell types was determined. The mesothelioma cell lines produced only minute amounts of hyaluronan (less than 0.1 microgram/10(6) cells/48 h) whereas mesothelial cells synthesized large quantities of hyaluronan (10-72 micrograms/10(6) cells/48 h). Conditioned media from the mesothelioma ...
متن کاملIn Vitro Testing of Modified Collagen/ Hyaluronan/beta-glucan Scaffold
Cells and scaffolds belong to main components of tissue engineering. In this study we have performed in vitro cytotoxicity and biocompatibility testing of modified collagen/hyaluronan/beta-glucan scaffold. We used direct contact assay as well as MTT test. Human adipose tissue-derived stem cells were used as biological model. According to obtained results, we can summarize, that modified collage...
متن کاملChemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding.
The accumulation of the extracellular matrix glycosaminoglycan hyaluronan by tumours and tumour-associated stroma promotes cancer cell invasion and metastasis. Using the Dunn chamber chemotaxis assay, we demonstrate for the first time that high molecular mass hyaluronan acts as a soluble chemoattractant promoting the directional migration of MDA-MB-468 and MDA-MB-231 breast cancer cells. Moreov...
متن کاملRegulated Hyaluronan Synthesis by Vascular Cells
Cellular microenvironment plays a critical role in several pathologies including atherosclerosis. Hyaluronan (HA) content often reflects the progression of this disease in promoting vessel thickening and cell migration. HA synthesis is regulated by several factors, including the phosphorylation of HA synthase 2 (HAS2) and other covalent modifications including ubiquitination and O-GlcNAcylation...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2006
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(07)60827-9